Yayınlanmış 1 Ocak 2020 | Sürüm v1

Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels

  • 1. Gaziantep Univ, Fac Med, Dept Physiol, TR-27310 Gaziantep, Turkey
  • 2. Medipol Univ, Fac Med, Dept Physiol, Istanbul, Turkey
  • 3. Firat Univ, Fac Med, Dept Med Biol, TR-23119 Elazig, Turkey
  • 4. Yozgat Bozok Univ, Dept Physiol, Fac Med, Yozgat, Turkey

Açıklama

Oxidative stress-induced Ca2+ permeable transient receptor potential melastatin 2 (TRPM2) channels are expressed at high levels in the brain, appear to link neuronal excitability to cellular metabolism, and are involved in the pathogenesis of neurodegenerative disorders. We aimed to study the electrophysiological properties of TRPM2 channels in stellate cells of the mouse ventral cochlear nucleus (VCN) using molecular, immunohistochemical and electrophysiological approaches.

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