Published January 1, 2015
| Version v1
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Overexpression of miR-145-5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression
Authors/Creators
- 1. Yeditepe Univ, Sch Med, Dept Med Genet, Istanbul, Turkey
- 2. Yeditepe Univ, Sch Med, Dept Med Pathol, Istanbul, Turkey
- 3. Istanbul Medeniyet Univ, Dept Urol, Istanbul, Turkey
- 4. Afyon Kocatepe Univ, Sch Med, Dept Med Genet, Afyon, Turkey
- 5. Baylor Coll Med, Div Biostat, Houston, TX 77030 USA
- 6. Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA
Description
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.
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