Yayınlanmış 1 Ocak 2020
| Sürüm v1
Dergi makalesi
Açık
Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity
Yazarlar/Oluşturanlar
- 1. Ataturk Univ, Erzurum Vocat Sch, Dept Food Qual & Anal, Erzurum, Turkey
- 2. Ataturk Univ, Fac Fisheries, Aquat Biotechnol Lab, Erzurum, Turkey
- 3. Ataturk Univ, Fac Vet, Dept Pathol, Erzurum, Turkey
- 4. Ataturk Univ, Fac Agr, Dept Food Engn, Erzurum, Turkey
- 5. Ataturk Univ, Fac Fisheries, Dept Basic Sci, TR-25240 Erzurum, Turkey
Açıklama
The toxicity of sodiumcarboxymethyl cellulose (CMC), which has GRAS status and has been determined as "ADI non specified", was re-evaluated with a new modelling and molecular-based data. For this purpose, CMC, a food additive, was injected to the yolk sac (food) of the zebrafish embryo by the microinjection method at the 4th hour of fertilization at different concentrations. As a result, it was found that CMC showed no toxic effects within the framework of the parameters studied. But, we determined increasing lipid accumulation in zebrafish embryos exposed to CMC in a dose-dependent manner. To elucidate the mechanism underlying this lipid accumulation, the expression levels of genes related to obesity-linked lipid metabolism were examined. Our findings show that while CMC does not cause a toxic effect in zebrafish embryos, it can lead important effects on lipid metabolism by causing changes in the expression of some genes associated with obesity. (C) 2020 Elsevier B.V. All rights reserved.
Dosyalar
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Dosyalar
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