Core/shell type, Ce3+ and Tb3+ doped GdBO3 system: Synthesis and Celecoxib drug delivery application

In this study, luminescent and magnetic core/shell Gd1- x-yCexTbyBO3@SiO2 nanoparticles were synthesized and used to design a drug delivery system for Celecoxib (CLX). CLX was chosen as the model drug because it is a nonstemidal anti-inflammatory drug that is highly hydrophobic with relatively low bioavailability. The core was synthesized by Pechini sol-gel method and silica coating was carried out by a Modified StOber method. Drug loading was carried out in ethanol with high efficiency and an improved drug dissolution was obtained in phosphate-buffered saline (PBS) at pH 7.4. Dissolution rate of CLX adsorbed onto the drug carrier at different pH conditions were examined and compared.