Yayınlanmış 1 Ocak 2016
| Sürüm v1
Dergi makalesi
Açık
The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain
Yazarlar/Oluşturanlar
- 1. Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Med Coll Virginia Campus, Richmond, VA 23298 USA
- 2. Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA
- 3. Uludag Univ, Dept Pharmacol, Fac Med, Bursa, Turkey
- 4. Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL USA
Açıklama
Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.
Dosyalar
bib-d38c1e9e-60dd-4f2e-8c87-9defe64c50be.txt
Dosyalar
(348 Bytes)
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348 Bytes | Ön İzleme İndir |