TUBITAK Destekli Projelerden Çıkan Yayınlar Topluluğu
Yayınlanmış 1 Ocak 2016 | Sürüm v1
Dergi makalesi Açık

Cell type specificity of neurovascular coupling in cerebral cortex

Yazarlar/Oluşturanlar

  • 1. Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
  • 2. Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
  • 3. Harvard Med Sch, Martinos Ctr Biomed Imaging, Charlestown, MA USA
  • 4. Norwegian Univ Life Sci, Dept Math Sci & Technol, As, Norway
  • 5. Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
  • 6. Univ Calif San Diego, Biol Undergrad Program, La Jolla, CA 92093 USA
  • 7. Univ Calif San Diego, Neurosci Grad Program, La Jolla, CA 92093 USA
  • 8. Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
  • 9. Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA

Açıklama

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

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