Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1
Yazarlar/Oluşturanlar
- 1. Univ Szeged, Dept Pharmacognosy, Szeged, Hungary
- 2. Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, Szeged, Hungary
- 3. Univ Szeged, Fac Pharm, Inst Pharmaceut Anal, Szeged, Hungary
Açıklama
Background: Transient Receptor Potential Vanilloid 1 (TRPV1) confers noxious heat and inflammatory pain signals in the peripheral nervous system. Clinical trial of resiniferatoxin from Euphorbia species is successfully aimed at TRPV1 in cancer pain management and heading toward new selective painkiller status that further validates this target for drug discovery efforts. Evodia species, used in traditional medicine for hundreds of years, are a recognised source of different TRPV1 agonists, but no antagonist has yet been reported.
Dosyalar
bib-eb40c865-4aaf-40e4-a2be-ab0e6520077e.txt
Dosyalar
(247 Bytes)
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md5:e441a42ad4b2e8a561c35e8091ec4fa2
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247 Bytes | Ön İzleme İndir |