Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
Cellular Model of Alzheimer's Disease: A beta(1-42) Peptide Induces Amyloid Deposition and a Decrease in Topo Isomerase II beta and Nurr1 Expression
Yazarlar/Oluşturanlar
- 1. Bezmialem Vakif Univ, Dept Med Biol, Fac Med, TR-34093 Istanbul, Turkey
- 2. Bahcesehir Univ, Dept Med Biochem, Fac Med, Istanbul, Turkey
- 3. Namik Kemal St 59-8, TR-34310 Istanbul, Turkey
- 4. Tuna St 51, TR-34040 Istanbul, Turkey
- 5. EMC Technol Inc, Biotechnol Res Lab, ARGEM Bldg, TR-34320 Istanbul, Turkey
Açıklama
Background: DNA topoisomerase II beta (topo II beta) plays a crucial role in neural differentiation and axonogenesis. Inhibition of topo II beta activity in vitro and in vivo results in shorter axons and increased DNA damage. These molecular events also involve in Alzheimer's disease (AD); however, the role of topo II beta in the pathogenesis of AD remains to be elucidated.
Dosyalar
bib-6e51288b-4491-47ec-a7b0-e1e9eb4e0708.txt
Dosyalar
(267 Bytes)
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md5:22403ffce813e3a9eb5ab20629c43bc4
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267 Bytes | Ön İzleme İndir |