Yayınlanmış 1 Ocak 2009
| Sürüm v1
Dergi makalesi
Açık
Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo
Yazarlar/Oluşturanlar
- 1. Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
- 2. Istanbul Univ, Dept Pharmacol, Fac Pharm, Istanbul, Turkey
- 3. Univ Amsterdam, Acad Med Ctr, AMC Liver Ctr, NL-1105 AZ Amsterdam, Netherlands
- 4. Netherlands Canc Inst, Div Clin Chem, NL-1066 CX Amsterdam, Netherlands
Açıklama
Purpose: ABCC2 (MRP2) and ABCG2 (BCRP) transport various endogenous and exogenous compounds, including many anticancer drugs, into bile, feces, and urine. We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX).
Dosyalar
bib-c42d3508-5a8b-4521-9bbb-82f8ce86c0e2.txt
Dosyalar
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368 Bytes | Ön İzleme İndir |