Yayınlanmış 1 Ocak 2018 | Sürüm v1

The Association Between The Extended Psychosis Phenotype and COMT val158met and BDNF val66met Polymorphisms

  • 1. Dokuz Eylul Univ, Fac Med, Dept Psychiat, Izmir, Turkey
  • 2. Yozgat City Hosp, Dept Psychiat, Yozgat, Turkey
  • 3. Ege Univ, Fac Med, Dept Psychiat, Izmir, Turkey
  • 4. Ege Univ, Fac Med, Dept Med Genet, Izmir, Turkey
  • 5. Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Psychol, Med Ctr, Maastricht, Netherlands

Açıklama

Objective: Psychotic disorders were previously associated with catechol-O-methyltransferase (COMT) val(158)met (rs4680) and brain-derived neurotrophic factor (BDNF) val(66) met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences.

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