Yayınlanmış 1 Ocak 2018
| Sürüm v1
Dergi makalesi
Açık
Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes
Yazarlar/Oluşturanlar
- 1. Amasya Univ, Fac Art & Sci, Dept Biol, TR-05100 Amasya, Turkey
- 2. Gebze Tech Univ, Dept Chem, TR-41400 Kocaeli, Turkey
- 3. Anadolu Univ, Dept Biol, TR-26470 Eskisehir, Turkey
- 4. Ondokuz Mayis Univ, Vacat Higher Sch Hlth Serv, Dept Med Serv & Tech, TR-55139 Samsun, Turkey
- 5. UEKAE BILGEM Sci & Technol Res Council Turkey TUB, Bioelect Devices & Syst Grp, TR-41470 Gebze, Turkey
Açıklama
In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, H-1, P-31 NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA.
Dosyalar
bib-0702c75a-87e0-4d32-9b2c-a9a1e28c4472.txt
Dosyalar
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