Yayınlanmış 1 Ocak 2021
| Sürüm v1
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Açık
Biodegradable Poly(lactic acid) Stabilized Nanoemulsions for the Treatment of Multidrug-Resistant Bacterial Biofilms
Yazarlar/Oluşturanlar
- 1. Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
Açıklama
Biofilm infections caused by multidrug-resistant (MDR) bacteria are an urgent global health threat. Incorporation of natural essential oils into biodegradable oil-in-water cross-linked polymeric nanoemulsions (X-NEs) provides effective eradication of MDR bacterial biofilms. The X-NE platform combines the degradability of functionalized poly(lactic acid) polymers with the antimicrobial activity of carvacrol (from oregano oil). These X-NEs exhibited effective penetration and killing of biofilms formed by pathogenic bacteria. Biofilm-fibroblast coculture models demonstrate that X-NEs selectively eliminate bacteria without harming mammalian cells, making them promising candidates for antibiofilm therapeutics.
Dosyalar
bib-f9618f4e-1aae-4af6-bd68-0496138b339c.txt
Dosyalar
(261 Bytes)
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