Yayınlanmış 1 Ocak 2011
| Sürüm v1
Dergi makalesi
Açık
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow
Yazarlar/Oluşturanlar
- 1. Baskent Univ, Fac Med, Dept Pharmacol, TR-06530 Ankara, Turkey
- 2. Hacettepe Univ, Fac Med, Dept Histol, Ankara, Turkey
- 3. Hacettepe Univ, Fac Med, Dept Neurol, Ankara, Turkey
- 4. Gazi Univ, Fac Med, Dept Neurol, Ankara, Turkey
Açıklama
Aims: To bring further insight into the mechanism of cyclosporine A (CsA)-induced hepatotoxicity, the acute effect of CsA on local hepatic blood flow (LHBF) and its association with systemic hemodynamics, histopathological and biochemical indicators of liver toxicity were studied in guinea pigs in vivo. The association of endothelin (ET) and/or Cremophor-EL (C-EL, vehicle in parenteral CsA preparation) with CsA effects was also investigated.
Dosyalar
bib-37168241-d38b-4d03-b1ac-ef61612e9159.txt
Dosyalar
(267 Bytes)
| Ad | Boyut | Hepisini indir |
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md5:142c823cb017b3e5e1bfc58a99aaac4e
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267 Bytes | Ön İzleme İndir |