Yayınlanmış 1 Ocak 2011 | Sürüm v1

Intracellular free zinc during cardiac excitation-contraction cycle: calcium and redox dependencies

  • 1. Ankara Univ, Fac Med, Dept Biophys, TR-06100 Ankara, Turkey
  • 2. CHU Arnaud de Villeneuve, INSERM, U637, Montpellier, France

Açıklama

Aims Zinc exists in biological systems as bound and histochemically reactive free Zn2+. It is an essential structural constituent of many proteins, including enzymes from cellular signalling pathways, in which it functions as a signalling molecule. In cardiomyocytes at rest, Zn2+ concentration is in the nanomolar range. Very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function.

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