Yayınlanmış 1 Ocak 2013 | Sürüm v1

Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

  • 1. Dokuz Eylul Univ, Inst Hlth Sci, Izmir, Turkey
  • 2. Dokuz Eylul Univ, Dept Anesthesiol & Reanimat, Izmir, Turkey
  • 3. Dokuz Eylul Univ, Dept Histol, Izmir, Turkey
  • 4. Dokuz Eylul Univ, Dept Microbiol, Izmir, Turkey

Açıklama

BACKGROUND: Lymphoid apoptosis in sepsis is associated with poor outcome, and prevention of apoptosis frequently improves survival in experimental models of sepsis. Recently, erythropoietin (EPO) was shown to protect against lipopolysaccharide (LPS)-induced mortality. As cecal ligation and puncture (CLP) is a clinically more relevant model of sepsis, we evaluated the effect of EPO on CLP-induced lymphoid tissue apoptosis and mortality.

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